Publications

Our team members have contributed to numerous peer-reviewed scientific publications addressing toxicological and safety evaluations of food ingredients, reflecting our experience in study design, data interpretation, and regulatory-relevant reporting. Representative publications include:

  1. Modica V, Glávzits R, Clewell A, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae. Int J Toxicol. 2025 Nov-Dec;44(6):471-487. doi: 10.1177/10915818251367353. Epub 2025 Aug 29. PMID: 40878581.

  2. Choi B, Glávits R, Clewell A, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. An Evaluation of Genotoxicity and 90-Day Repeated-Dose Oral Toxicity in Rats of DracoBelle Nu sd. Food Sci Nutr. 2025 Oct 9;13(10):e71060. doi: 10.1002/fsn3.71060. PMID: 41078448; PMCID: PMC12510896.

  3. Choi B, Glávits R, Murbach TS, Endres JR, Hirka G, Szakonyiné IP. 90-day oral toxicity study in rats of a protein-rich powder derived from Xanthobacter sp. SoF1. J Appl Toxicol. 2024 Nov;44(11):1816-1830. doi: 10.1002/jat.4663. Epub 2024 Aug 4. PMID: 39098047.

  4. Murbach TS, Glávits R, Endres JR, Hirka G, Vértesi A, Béres E, Pasics Szakonyiné I. An evaluation of the genotoxicity and 90-day repeated dose oral toxicity in rats of Porphyridium purpureum. J Appl Toxicol. 2024 Oct;44(10):1616-1632. doi: 10.1002/jat.4665. Epub 2024 Jul 1. PMID: 38950973.

  5. Murbach TS, Glávits R, Endres JR, Hirka G, Pasics Szakonyiné I. A 90-day preclinical toxicological evaluation in rats of a highly purified and concentrated mulberry leaf extract. J Appl Toxicol. 2024 Oct;44(10):1504-1517. doi: 10.1002/jat.4644. Epub 2024 Jun 4. PMID: 38837228.

  6. Clewell A, Glávits R, Endres JR, Murbach TS, Báldi PT, Renkecz T, Hirka G, Vértesi A, Béres E, Szakonyiné IP. An evaluation of the genotoxicity and 90-day repeated-dose toxicity of a CBD-rich hemp oil. J Appl Toxicol. 2023 Nov;43(11):1719-1747. doi: 10.1002/jat.4511. Epub 2023 Jul 28. PMID: 37501578.

  7. Dunn M, Glávits R, Murbach TS, Modica V, Endres JR, Hirka G, Pasics Szakonyiné I. A 90-day toxicity study of tripeptide, arginine-alanine-lysine. J Appl Toxicol. 2023 Sep;43(9):1332-1346. doi: 10.1002/jat.4468. Epub 2023 Apr 2. PMID: 36946007.

  8. Murbach TS, Glávits R, Jayasena S, Moghadam Maragheh N, Endres JR, Hirka G, Goodman RE, Vértesi A, Béres E, Pasics Szakonyiné I. Toxicology and digestibility of Chlamydomonas debaryana green algal biomass. J Appl Toxicol. 2023 Jul;43(7):993-1012. doi: 10.1002/jat.4438. Epub 2023 Feb 15. PMID: 36680512.

  9. Modica V, Glávits R, Murbach TS, Endres JR, Hirka G, Vértesi A, Béres E, Pasics Szakonyiné I. Toxicological evaluation of protein powder derived from Cupriavidus necator. J Appl Toxicol. 2023 Jun;43(6):887-912. doi: 10.1002/jat.4432. Epub 2023 Jan 26. PMID: 36598355.

  10. Preece KE, Glávits R, Murbach TS, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Safety evaluation of Veillonella atypica FB0054 with genotoxicity and subchronic toxicological studies. J Appl Toxicol. 2023 Jun;43(6):808-827. doi: 10.1002/jat.4426. Epub 2023 Jan 6. PMID: 36547222.

  11. Murbach TS, Glávits R, Moghadam Maragheh N, Endres JR, Hirka G, Goodman RE, Lu G, Vértesi A, Béres E, Pasics Szakonyiné I. Evaluation of the genotoxic potential of protoporphyrin IX and the safety of a protoporphyrin IX-rich algal biomass. J Appl Toxicol. 2022 Jul;42(7):1253-1275. doi: 10.1002/jat.4293. Epub 2022 Feb 15. PMID: 35104912.

  12. Modica V, Glávits R, Murbach TS, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A toxicological evaluation of 8-28 nm gold nanocrystals. Food Chem Toxicol. 2022 Mar;161:112844. doi: 10.1016/j.fct.2022.112844. Epub 2022 Feb 5. PMID: 35134458.

  13. Murbach TS, Glávits R, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A toxicological evaluation of lithium orotate. Regul Toxicol Pharmacol. 2021 Aug;124:104973. doi: 10.1016/j.yrtph.2021.104973. Epub 2021 Jun 17. PMID: 34146638.

  14. Preece K, Glávits R, Foster JR, Murbach T, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A toxicological evaluation of geranylgeraniol. Regul Toxicol Pharmacol. 2021 Aug;124:104975. doi: 10.1016/j.yrtph.2021.104975. Epub 2021 Jun 16. PMID: 34144118.

  15. Preece KE, Glávits R, Murbach TS, Endres JR, Hirka G, Vértesi A, Szakonyiné IP. Assessment of toxicological potential of sodium carboxymethyl beta-glucan, a novel beta-glucan. Food Chem Toxicol. 2021 Jun;152:112226. doi: 10.1016/j.fct.2021.112226. Epub 2021 Apr 24. PMID: 33905759.

  16. Preece KE, Glávits R, Murbach T, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A toxicological evaluation of monomethylsilanetriol (MMST) stabilized in acacia gum, a novel silicon preparation. Regul Toxicol Pharmacol. 2020 Nov;117:104782. doi: 10.1016/j.yrtph.2020.104782. Epub 2020 Sep 6. PMID: 32905813.

  17. Murbach TS, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Pasics Szakonyiné I. A toxicological evaluation of a fulvic and humic acids preparation. Toxicol Rep. 2020 Sep 14;7:1242-1254. doi: 10.1016/j.toxrep.2020.08.030. PMID: 32995299; PMCID: PMC7505752.

  18. Reddeman RA, Glávits R, Endres JR, Murbach TS, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium). J Toxicol. 2020 Apr 4;2020:6275625. doi: 10.1155/2020/6275625. PMID: 32322266; PMCID: PMC7160733.

  19. Murbach TS, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Methylliberine (Dynamine®). J Toxicol. 2019 Oct 27;2019:4981420. doi: 10.1155/2019/4981420. PMID: 31911801; PMCID: PMC6930730.

  20. Reddeman RA, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. J Toxicol. 2019 Aug 1;2019:4763015. doi: 10.1155/2019/4763015. PMID: 31467524; PMCID: PMC6699309.

  21. Murbach TS, Glávits R, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®). J Toxicol. 2019 Jul 1;2019:5723851. doi: 10.1155/2019/5723851. PMID: 31354815; PMCID: PMC6633876.

  22. Thiel A, Glávits R, Murbach TS, Endres JR, Reddeman R, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Toxicological evaluations of colostrum ultrafiltrate. Regul Toxicol Pharmacol. 2019 Jun;104:39-49. doi: 10.1016/j.yrtph.2019.02.017. Epub 2019 Mar 1. PMID: 30831157.

  23. Palmer PA, Bryson JA, Clewell AE, Endres JR, Hirka G, Vértesi A, Béres E, Glávits R, Szakonyiné IP. A comprehensive toxicological safety assessment of an extract of Ageratum conyzoides. Regul Toxicol Pharmacol. 2019 Apr;103:140-149. doi: 10.1016/j.yrtph.2019.01.027. Epub 2019 Jan 23. PMID: 30684565.

  24. Marx TK, Reddeman R, Clewell AE, Endres JR, Béres E, Vértesi A, Glávits R, Hirka G, Szakonyiné IP. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. J Toxicol. 2018 Jun 7;2018:8143582. doi: 10.1155/2018/8143582. PMID: 29977291; PMCID: PMC6011091.

  25. Reddeman RA, Glávits R, Endres JR, Murbach TS, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Assessment of Creatyl-l-Leucine. Int J Toxicol. 2018 Mar/Apr;37(2):171-187. doi: 10.1177/1091581817751142. Epub 2018 Jan 22. PMID: 29357766.

  26. Murbach TS, Glávits R, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Chlamydomonas reinhardtii, a Green Algae. Int J Toxicol. 2018 Jan/Feb;37(1):53-62. doi: 10.1177/1091581817746109. Epub 2018 Jan 5. PMID: 29303016.

  27. Murbach TS, Glávits R, Hirka G, Endres JR, Clewell AE, Szakonyiné IP. A 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock®). Toxicol Rep. 2017 Sep 12;4:494-501. doi: 10.1016/j.toxrep.2017.09.002. PMID: 28959679; PMCID: PMC5615158.

  28. Marx TK, Glávits R, Endres JR, Palmer PA, Clewell AE, Murbach TS, Hirka G, Pasics I. A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of Morus Alba L. Int J Toxicol. 2016 Nov;35(6):683-691. doi:10.1177/1091581816670597. Epub 2016 Oct 12. PMID: 27733446.

  29. Clewell AE, Béres E, Vértesi A, Glávits R, Hirka G, Endres JR, Murbach TS, Szakonyiné IP. A Comprehensive Toxicological Safety Assessment of an Extract of Olea Europaea L. Leaves (Bonolive™). Int J Toxicol. 2016 Mar-Apr;35(2):208-21. doi: 10.1177/1091581815619764. Epub 2015 Dec 10. PMID: 26658007.

  30. Clewell A, Hirka G, Glávits R, Palmer PA, Endres JR, Murbach TS, Marx T, Pasics Szakonyiné I. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. J Toxicol. 2016;2016:6206859. doi: 10.1155/2016/6206859. Epub 2016 Aug 22. PMID: 27635133; PMCID: PMC5011229.

  31. Murbach TS, Béres E, Vértesi A, Glávits R, Hirka G, Endres JR, Clewell AE, Szakonyiné IP. A comprehensive toxicological safety assessment of an aqueous extract of Polypodium leucotomos (Fernblock®). Food Chem Toxicol. 2015 Dec;86:328-41. doi: 10.1016/j.fct.2015.11.008. Epub 2015 Nov 14. PMID: 26585922.

  32. Murbach TS, Hirka G, Szakonyiné IP, Gericke N, Endres JR. A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin®) in rats. Food Chem Toxicol. 2014 Dec;74:190-9. doi: 10.1016/j.fct.2014.09.017. Epub 2014 Oct 6. PMID: 25301237.

  33. Odendaal AY, Deshmukh NS, Marx TK, Schauss AG, Endres JR, Clewell AE. Safety assessment of a hydroethanolic extract of Caralluma fimbriata. Int J Toxicol. 2013 Sep-Oct;32(5):385-94. doi: 10.1177/1091581813492827. Epub 2013 Jun 14. PMID: 23771637.

  34. Benson KF, Redman KA, Carter SG, Keller D, Farmer S, Endres JR, Jensen GS. Probiotic metabolites from Bacillus coagulans GanedenBC30™ support maturation of antigen-presenting cells in vitro. World J Gastroenterol. 2012 Apr 28;18(16):1875-83. doi: 10.3748/wjg.v18.i16.1875. PMID: 22563167; PMCID: PMC3337562.

  35. Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J Agric Food Chem. 2012 Apr 25;60(16):4096-101. doi: 10.1021/jf205295u. Epub 2012 Apr 16. PMID: 22486722.

  36. Ruff KJ, Endres JR, Clewell AE, Szabo JR, Schauss AG. Safety evaluation of a natural eggshell membrane-derived product. Food Chem Toxicol. 2012 Mar;50(3-4):604-11. doi: 10.1016/j.fct.2011.12.036. Epub 2012 Jan 3. PMID: 22245377.

  37. Clewell A, Barnes M, Endres JR, Ahmed M, Ghambeer DK. Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial. J Drugs Dermatol. 2012 Feb;11(2):209-15. PMID: 22270204.

  38. Schauss AG, Glavits R, Endres J, Jensen GS, Clewell A. Safety evaluation of a proprietary food-grade, dried fermentate preparation of Saccharomyces cerevisiae. Int J Toxicol. 2012 Jan-Feb;31(1):34-45. doi: 10.1177/1091581811425195. Epub 2012 Jan 5. PMID: 22222580.

  39. Schauss AG, Béres E, Vértesi A, Frank Z, Pasics I, Endres J, Aruoma OI, Hirka G. The effect of ergothioneine on clastogenic potential and mutagenic activity: genotoxicity evaluation. Int J Toxicol. 2011 Aug;30(4):405-9. doi: 10.1177/1091581811405856. Epub 2011 Jul 19. PMID: 21772023.

  40. Endres JR, Qureshi I, Farber T, Hauswirth J, Hirka G, Pasics I, Schauss AG. One-year chronic oral toxicity with combined reproduction toxicity study of a novel probiotic, Bacillus coagulans, as a food ingredient. Food Chem Toxicol. 2011 May;49(5):1174-82. doi: 10.1016/j.fct.2011.02.012. Epub 2011 Feb 19. PMID: 21338652.

  41. Schauss AG, Vértesi A, Endres JR, Hirka G, Clewell A, Qureshi I, Pasics I. Evaluation of the safety of the dietary antioxidant ergothioneine using the bacterial reverse mutation assay. Toxicology. 2010 Nov 28;278(1):39-45. doi: 10.1016/j.tox.2010.07.015. Epub 2010 Jul 30. PMID: 20674647.

  42. Clewell A, Qureshi I, Endres J, Horváth J, Financsek I, Neal-Kababick J, Jade K, Schauss AG. Toxicological evaluation of a dietary supplement formulated for male sexual health prior to market release. Regul Toxicol Pharmacol. 2010 Jun;57(1):55-61. doi: 10.1016/j.yrtph.2009.12.006. Epub 2010 Jan 4. PMID: 20043970.

  43. Jensen GS, Benson KF, Carter SG, Endres JR. GanedenBC30 cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro. BMC Immunol. 2010 Mar 24;11:15. doi: 10.1186/1471-2172-11-15. PMID: 20331905; PMCID: PMC2858026.

  44. Farber TM, Clewell AE, Endres JR, Hauswirth J, Van Gemert M, Schauss AG, Sheane CA. Safety assessment of a novel ingredient for removable chewing gum. Food Chem Toxicol. 2010 Mar;48(3):831-8. doi: 10.1016/j.fct.2009.12.017. Epub 2009 Dec 24. PMID: 20035819.

  45. Schauss AG, Somfai-Relle S, Financsek I, Glavits R, Parent SC, Endres JR, Varga T, Szücs Z, Clewell A. Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats. Int J Toxicol. 2009 Nov-Dec;28(6):479-87. doi: 10.1177/1091581809349452. PMID: 19966140.

  46. Endres JR, Clewell A, Jade KA, Farber T, Hauswirth J, Schauss AG. Safety assessment of a proprietary preparation of a novel Probiotic, Bacillus coagulans, as a food ingredient. Food Chem Toxicol. 2009 Jun;47(6):1231-8. doi: 10.1016/j.fct.2009.02.018. Epub 2009 Feb 25. PMID: 19248815; PMCID: PMC2726964.

  47. Jensen GS, Wu X, Patterson KM, Barnes J, Carter SG, Scherwitz L, Beaman R, Endres JR, Schauss AG. In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. J Agric Food Chem. 2008 Sep 24;56(18):8326-33. doi: 10.1021/jf8016157. Epub 2008 Aug 22. PMID: 18717569.

  48. Honzel D, Carter SG, Redman KA, Schauss AG, Endres JR, Jensen GS. Comparison of chemical and cell-based antioxidant methods for evaluation of foods and natural products: generating multifaceted data by parallel testing using erythrocytes and polymorphonuclear cells. J Agric Food Chem. 2008 Sep 24;56(18):8319-25. doi: 10.1021/jf800401d. Epub 2008 Aug 22. PMID: 18717566.